To further identify amino acid domains involved in the ligand binding specificity of α IIb β 3,
chimeras of the conserved calcium binding domains of α IIb and the α subunit of the …

Calcium-binding domains in the α-subunit of integrins contain a central loop structure. To
examine the importance of the loop structure, a series of αIIb mutants containing changes to …

Integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) is a prototype of integrins involved in
cellular adhesive functions. As part of a structure-function analysis of this molecule, we …

Structural data of integrin αIIbβ3 have been interpreted as supporting a model in which: 1)
the receptor exists primarily in a" bent," low affinity conformation on unactivated platelets and …

Abstract The Calcium Integrin Binding protein (CIB) has been identified as interacting
specifically with the cytoplasmic tail of the integrin α IIb domain to induce receptor activation …

This work characterizes a mutant integrin alpha IIb beta 3 (glycoprotein (GP) IIb-IIIa) from a
thrombasthenic patient, ET, whose platelets fail to aggregate in response to stimuli. The …

The α M β 2 integrin plays an important role in leukocyte biology through its interactions with
a diverse set of ligands. Efficient ligand binding requires the involvement of both the α M and …

Integrin alpha IIb-beta 3 binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser
(RGDS). We have used the baculovirus/insect cell expression system to study the structural …

The A-domains within integrin β subunits contain three metal sites termed the metal ion-
dependent adhesion site (MIDAS), site adjacent to the metal ion-dependent adhesion site …

Adhesive interactions of platelet integrin αIIbβ3 with fibrinogen and fibrin are central events
in hemostasis and thrombosis. However, the mechanisms by which αIIbβ3 binds these …