Histones are the predominant protein components of chromatin and are subject to specific
post-translational modifications that are correlated with transcriptional competence. Among …

Nucleocytoplasmic trafficking of histone deacetylase 4 (HDAC4) plays an important role in
regulating its function, and binding of 14-3-3 proteins is necessary for its cytoplasmic …

Histone acetyltranferase (HAT) enzymes are the catalytic subunits of multisubunit protein
complexes that acetylate specific lysine residues on the N-terminal regions of the histone …

Histone acetyltranferase (HAT) enzymes are the catalytic subunit of large multisubunit HAT
complexes that acetylate the ε-amino group of specific lysine residues on histone tails to …

The number of chromatin modifying and remodeling complexes implicated in genome
control is growing faster than our understanding of the functional roles they play. We discuss …

We present here an in vivo view of major histocompatibility complex (MHC) class II promoter
assembly, nucleosome modifications and gene expression mediated by the class II …

Deregulated expression of the c-myc proto-oncogene contributes to malignant progression
of a variety of tumors. The c-Myc protein (or Myc) is a transcription factor that positively or …

Genetic mechanisms regulating CNS progenitor function and differentiation are not well
understood. We have used microarrays derived from a representational difference analysis …

Post-translational acetylation of core histones is an enigmatic process. The identification of
histone acetyltransferases and deacetylases as co-regulators of transcription in yeast and …

Factor acetyltransferase activity associated with several histone acetyltransferases plays a
key role in the control of transcription. Here we report that hGCN5, a well known histone …