Alteration of chromatin is central to genomic regulation. Chromatin is composed of
nucleosomes which are particles consisting of DNA in association with an octamer of two …

Abstract p300 and CBP participate as transcriptional coregulators in the execution of a wide
spectrum of cellular gene expression programs controlling cell differentiation, growth and …

The promoter regions of MHC class I and β 2-microglobulin (β 2 m) genes posses a
regulatory module consisting of S, X, and Y boxes, which is shared by MHC class II and its …

The nuclear hormone receptor superfamily is composed of a group of hormone-dependent
transcription factors that play prominent roles in homeostatic events in vertebrates. A …

The tumor suppressor protein p53 is a transcription factor that is frequently mutated in
human cancers. In response to DNA damage, p53 protein is stabilized and activated by post …

The seven member, human MORF4relatedgene (MRG) family was recently identified based
on the ability of Mortalityfactoronchromosome4 (MORF4) to induce replicative senescence in …

Cell proliferation and differentiation are guided by changes in gene expression and require
the coordinated efforts of the transcription machinery and chromatin-remodeling factors …

Acetylation of nucleosomal histones is a major regulatory step during activation of eukaryotic
gene expression. Among the known acetyltransferase (AT) families, the structure–function …

The MCM proteins are essential for the initiation of DNA replication. We have isolated an
MCM3‐associated protein (MCM3AP) in a two‐hybrid screen using MCM3. Here we …

The Rpd3 histone deacetylase (HDAC) functions in a large complex containing many
proteins including Sin3 and Sap30. Previous evidence indicates that the pho23, rpd3, sin3 …