The adenovirus E1A protein regulates transcription of cellular genes via its interaction with
the transcriptional coactivators p300/CBP. The collagenase promoter activated by the c‐Jun …

Histone acetyltransferases (HATs) such as Gcn5 play a role in transcriptional activation.
However, the majority of constitutive genes show no requirement for GCN5, and even …

In all eukaryotes, multisubunit histone acetyltransferase (HAT) complexes acetylate the
highly conserved lysine residues in the amino-terminal tails of core histones to regulate …

Gene activity in a eukaryotic cell is regulated by accessory factors to RNA polymerase II,
which include the general transcription factor complex TFIID, composed of TBP and TBP …

HIV-1 Tat is able to form a ternary complex with P/CAF and p300 and increase the affinity for
CDK9/P-TEFb CTD kinase complex. Our previous study demonstrated that Tat binds to …

The group IV cytosolic phospholipase A2 (cPLA2) has been localized to the nucleus (MR
Sierra-Honigmann, JR Bradley, and JS Pober, Lab. Investig. 74: 684–695, 1996) and is …

Histone acetylation plays an important role in remodeling chromatin structure, facilitating
nuclear processes such as transcription. We investigated the effect of estradiol on global …

Epigenetic regulation involves the maintenance of a particular state of gene expression—
most commonly, repression—in the face of repeated mitosis, and frequently meiosis …

Altering chromatin structure by blocking histone deacetylase activity with specific inhibitors
such as trichostatin A can result in an up-regulation of gene expression. In this report …

Several post‐translational modifications of lysine residues of lens proteins have been
implicated in cataractogenesis. In the present study, the molecular weight of an α‐crystallin …