Regulation of transcription factor YY1 by acetylation and deacetylation

YL Yao, WM Yang, E Seto - Molecular and cellular biology, 2001 - Taylor & Francis
YY1 is a sequence-specific DNA-binding transcription factor that has many important
biological roles. It activates or represses many genes during cell growth and differentiation …

Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?

MJ Thomas, E Seto - Gene, 1999 - Elsevier
The transcription factor YY1 is a complex protein that is involved in repressing and activating
a diverse number of promoters. Numerous studies have attempted to understand how this …

Multiple mechanisms of transcriptional repression by YY1

KM Galvin, Y Shi - Molecular and cellular biology, 1997 - Am Soc Microbiol
The four C-terminal GLI-Krüppel type zinc fingers of YY1 have been identified as a
transcriptional repression domain. Previous reports have proposed DNA-bending and …

Molecular cloning and functional characterization of the transcription factor YY2

N Nguyen, X Zhang, N Olashaw, E Seto - Journal of Biological Chemistry, 2004 - ASBMB
YY1 is a ubiquitous zinc finger transcription factor that binds to and regulates promoters and
enhancers of many cellular and viral genes. Here we report the isolation of a human cDNA …

Transcription factor YY1: structure, function, and therapeutic implications in cancer biology

S Gordon, G Akopyan, H Garban, B Bonavida - Oncogene, 2006 - nature.com
The ubiquitous transcription factor Yin Yang 1 (YY1) is known to have a fundamental role in
normal biologic processes such as embryogenesis, differentiation, replication, and cellular …

Regulation of the transcription factor YY1 in mitosis through phosphorylation of its DNA-binding domain

R Rizkallah, MM Hurt - Molecular biology of the cell, 2009 - Am Soc Cell Biol
Yin-Yang 1 (YY1) is a ubiquitously expressed zinc finger transcription factor. It regulates a
vast array of genes playing critical roles in development, differentiation, and cell cycle. Very …

Characterization of Functional Domains within the Multifunctional Transcription Factor, YY1 (∗)

S Bushmeyer, K Park, ML Atchison - Journal of Biological Chemistry, 1995 - ASBMB
YY1 is a multifunctional transcription factor capable of either activation or repression of
transcription. Using a series of mutant proteins, we have characterized domains responsible …

Transcription factor YY1 binds to the murine beta interferon promoter and regulates its transcriptional capacity with a dual activator/repressor role

L Weill, E Shestakova, E Bonnefoy - Journal of virology, 2003 - Am Soc Microbiol
The induction of the beta interferon (IFN-β) gene constitutes one of the first responses of the
cell to virus infection. Its regulation is achieved through an intricate combination of virus …

The why of YY1: mechanisms of transcriptional regulation by Yin Yang 1

TCJ Verheul, L van Hijfte, E Perenthaler… - Frontiers in cell and …, 2020 - frontiersin.org
First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously
expressed throughout mammalian cells. It regulates both transcriptional activation and …

The two sides of YY1 in cancer: a friend and a foe

S Sarvagalla, SP Kolapalli, S Vallabhapurapu - Frontiers in oncology, 2019 - frontiersin.org
Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional
activation and repression of many genes associated with multiple cellular processes …