The nuclear expression and action of the nuclear factor kappa B (NF-κB) transcription factor
requires signal-coupled phosphorylation and degradation of the IκB inhibitors, which …

While the proximal cytoplasmic signalling events controlling the activation of NF‐κB are
understood in considerable detail, the subsequent intranuclear events that regulate the …

Although the proximal cytoplasmic signaling events that control the activation of the NF-κB
transcription factor are understood in considerable detail, the subsequent intranuclear …

Nuclear localization of the transcriptional activator NF-κB (nuclear factor κB) is controlled in
mammalian cells by three isoforms of NF-κB inhibitor protein: IκBα,-β, and-ɛ. Based on …

Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by
sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IκB. A …

IκB-α inhibits transcription factor NF-κB by retaining it in the cytoplasm. Various stimuli,
typically those associated with stress or pathogens, rapidly inactivate IκB-α. This liberates …

Regulation of NF-κB transactivation function is controlled at several levels, including
interactions with coactivator proteins. Here we show that the transactivation function of NF …

The eukaryotic transcription factor nuclear factor-kappa B (NF-κB) participates in many parts
of the genetic program mediating T lymphocyte activation and growth. Nuclear expression of …

Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from
inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB …

A large protein complex mediates the phosphorylation of the inhibitor of κB (IκB), which
results in the activation of nuclear factor κB (NF-κB). Two subunits of this complex, IκB kinase …