Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …

Successful medical use of interferon for chronic viral infections is increasingly dependent on
understanding the biologic and molecular mechanisms of the interferon system. Interferon …

Since the discovery of interferons (IFNs), considerable progress has been made in
describing the nature of the cytokines themselves, the signalling components that direct the …

To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …

The type I interferon (IFN) system responds to viral infection and induces an" antiviral state"
in cells, providing an important first line of defense against virus infection. Interaction of type I …

▪ Abstract The interferon system is the first line of defense against viral infection in mammals.
This system is designed to block the spread of virus infection in the body, sometimes at the …

Interferons represent a family of cytokines, which is of central importance in the innate
immune response to virus infections. All interferons act as secreted ligands of specific cell …

Publisher Summary This chapter emphasizes additional aspects of the part played by the
interferons (IFNs) in determining the outcome of encounters between viruses and host cells …

Considerable progress has been made in the understanding of the molecular biology of the
human interferon system. The genes encoding the interferons, their receptors, and the …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …