Post-translational addition of methyl groups to the amino-terminal tails of histone proteins
was discovered more than three decades ago. Only now, however, is the biological …

In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …

Histone methylation has important roles in regulating transcription, genome integrity and
epigenetic inheritance. Historically, methylated histone arginine and lysine residues have …

Histones are the major protein constituent of chromatin in the eukaryotic nucleus. These
proteins undergo a host of different post-translational modifications, including …

Histone methylation was first described more than 35 years ago, but its role has remained
enigmatic. Proposed functions range from transcriptional regulation to the higher-order …

Diverse post-translational modifications of histone amino termini represent an important
epigenetic mechanism for the organisation of chromatin structure and the regulation of gene …

Histone N-termini (tails) undergo diverse post-translational modifications, including
acetylation, phosphorylation, methylation, ubiquitination and ADP-ribosylation (van Holde …

Recent findings suggest that lysine and arginine-specific methylation of histones may
cooperate with other types of post-translational histone modification to regulate chromatin …

Histone lysine methylation plays a fundamental role in chromatin organization and function.
This epigenetic mark is involved in many biological processes such as heterochromatin …

Publisher Summary Histone N-terminal tails are subject to a variety of covalent modifications
that ultimately affect chromatin structure. One such modification is N-methylation, which …