1TQ ietters to the Editor because it is used commonly in patients with malignancy
complicated by deep vein thrombosis and can be given chronically on an outpatient basis …

The relation of cancer to thromboembolism has been described since the mid 1800s.
Different studies in animal and in vitro models have confirmed the link between the …

The association between thrombosis and cancer is well known and the first description of
venous thrombosis as a complication of malignant disease by Trousseau dates back to …

Pathology studies of human cancers suggested to early investigators that the hemostatic
system may play an important role in cancer metastasis. Subsequent studies in animal …

Recently reported large series have provided clear evidence of an association between
idiopathic thromboembolism and the development of cancer. The standardized incidence …

Cancer cells may promote fibrin formation in the tumor microenvironment through availability
of procoagulant activities which are mainly of two types: tissue thrombo plastin-like or direct …

Cells from some experimental tumors have been found to possess a peculiar procoagulant
activity, which directly activates coagulation factor X, independently of both the intrinsic and …

For more than 50 years, vitamin K has been thought to be uniquely involved in blood
coagulation. Unlike many other vitamins, its mode of action is known on a molecular level …

Vitamin K-deficiency (either dietary or pharmacologically induced) has been reported to
reduce metastasis formation in some experimental tumor models, among which the Lewis …

Because of the high risk of thrombosis, cancer patients often receive anticoagulants as
prophylaxis or treatment. It has been suggested that antithrombotic agents influence cancer …