Most gut peptides exert their effects through G protein-coupled receptors, a family of about
700 membrane proteins, 87 of which are presently known to have peptide ligands. Three …

Throughout the intestine there is diffuse endocrine tissue which synthesizes and releases a
variety of peptide hormones [1]. It is also richly innervated by extrinsic and intrinsic neurons …

The gastrointestinal tract as endocrine organ differs from the classic endocrine organs
fundamentally because its specialized endocrine cells are not confined in one distinct gland …

Leading clinical and basic science researchers present the latest molecular and cellular
findings on key gut peptides, illuminating their physiology and pathophysiology, as well as …

Receptors for regulatory peptides (hormones or neurotransmitters) play a pivotal role in the
ability of cells to taste the rich neuroendocrine environment of the gut. Recognition of low …

Research on neuro-and endocrine peptides in the gastrointestinal tract has expanded
markedly in the last 20 years. The information available has become so extensive that most …

Since the early seminal description of secretin by Bayliss and Starling more than 100 years
ago [1] and the critical observations by Edkins [2, 3], numerous gastrointestinal regulatory …

One fundamental concept of endocrinology states that certain messenger molecules, or
hormones (derived from the Greek horman [horman,'impel, urge on']), are directly secreted …

Signal peptides in the GI tract may be of endocrine, paracrine, or neuronal origin.
Improvements in the ability to identify cells containing such peptides and to measure them …

The digestive tract is equipped with a diffuse endocrine tissue which synthesizes and
releases a variety of peptide hormones. It is also richly innervated by extrinsic and intrinsic …