The fibrinolytic system in cancer Page 1 5 The fibrinolytic system in cancer Gilles Lugassy and
Abraham Klepfish The fibrinolytic (plasminogen–plasmin proteolytic enzyme) system is …

The fibrinolytic system comprises a proenzyme, plasminogen, which can be activated to the
active enzyme plasmin, that will degrade fibrin by different types of plasminogen activators …

During activation of the fibrinolytic system plasminogen is converted to plasmin by tissue
plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). t-PA is …

The topic of this review is the regulation of intravas-cular fibrinolysis in humans. The function
of the fibrinolytic system is the proteolytic degradation of fibrin and other structural proteins …

The fibrinolytic enzyme system is involved in many physiological and pathophysiologic
processes. Removal of fibrin deposits from blood vessels and prevention of formation of …

In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

All components of hemostasis, that is, the endothelial cells, the platelets, and the blood
coagulation-fibrinolytic system, might be involved in malignancy. While blood coagulation …

The high prevalence of hypercoagulative states in cancer patients has been known for more
than a century. Venous thrombosis in gastric cancer was described by Trousseau in 1865 …

Over the last several years, there has been an explosion of new discoveries in the field of
fibrinolysis. The cDNA and consequently the primary amino sequences of most of the …

Increased blood clotting and increased fibrinolytic activity are known to be associated with
malignant tumors and certain tumors, particularly those of the prostate, are capable of …