Expression and functions of the duodenal peptide secretin and its receptor in human lung

RJ Davis, KJ Page, GJ Dos Santos Cruz… - American journal of …, 2004 - atsjournals.org
The physiological role of the duodenal peptide secretin is as a potent stimulant of electrolyte
and water movement in pancreatic and biliary epithelium, via activation of G protein …

Molecular cloning and functional characterization of a human secretin receptor

BKC Chow - Biochemical and biophysical research communications, 1995 - Elsevier
Secretin is a gastrointestinal hormone responsible for the regulation of bicarbonate,
potassium ion and enzyme secretion from the pancreas. A cDNA encoding the human …

Molecular cloning and expression of a human secretin receptor.

DR Patel, Y Kong, SP Sreedharan - Molecular pharmacology, 1995 - ASPET
Secretin is a 27-amino acid neuroendocrine peptide that stimulates fluid and electrolyte
secretion in the gastrointestinal tract, activates tyrosine hydroxylase activity in the central …

Comparison of VIP-secretin receptors in rat and human lung

J Christophe, P Chatelain, G Taton, M Delhaye… - Peptides, 1981 - Elsevier
The binding of 125 I-VIP (Vasoactive Intestinal Peptide) to a crude particulate fraction from
rat lung was reversible and 125 I-VIP dissociation was accelerated by guanine triphosphate …

Secretoneurin is released into human airways by topical histamine but not capsaicin

M Korsgren, R Fischer‐Colbrie, M Andersson… - Allergy, 2005 - Wiley Online Library
Background: The neuropeptide secretoneurin, with potential relevance to leukocyte
trafficking, is present in nerves of the nasal mucosa in allergic rhinitis and may be released …

Expression and Motor Effects of Secretin in Small and Large Intestine of the Rat☆, 1

A Andersson, F Sundler, E Ekblad - Peptides, 2000 - Elsevier
Immunocytochemistry and in situ hybridization revealed abundant secretin expressing cells
on duodenal villi with a gradual decrease throughout the small intestines of the rat. They …

Secretin receptor activity in rat gastric glands. Binding studies, cAMP generation and pharmacology

C Gespach, D Bataille, N Vauclin, L Moroder… - Peptides, 1986 - Elsevier
We measured 125 I-secretin binding to memebranes prepared from rat fundic glands and
compared the abilities of natural and synthetic secretin (SN) analogs to inhibit 125 I-secretin …

Importance of each residue within secretin for receptor binding and biological activity

M Dong, A Le, JA Te, DI Pinon, AJ Bordner… - Biochemistry, 2011 - ACS Publications
Secretin is a linear 27-residue peptide hormone that stimulates pancreatic and biliary
ductular bicarbonate and water secretion by acting at its family BG protein-coupled receptor …

Secretin, 100 years later

WY Chey, TM Chang - Journal of gastroenterology, 2003 - Springer
One hundred years have elapsed since the discovery of secretin by Bayliss and Starling in
1902. In the past century, the research of secretin has gone by many milestones including …

Secretin receptors mediating rat forestomach relaxation

TS Steiner, AW Mangel, DC McVey… - American Journal of …, 1993 - journals.physiology.org
Frozen sections of the rat stomach were incubated with 125I-labeled porcine secretin, and
then secretin binding sites were localized by autoradiography. Saturable binding was …