[PDF][PDF] Short N-terminal regions of the calcitonin-like receptor define ligand specificity

D Koller - 2004 - research-collection.ethz.ch
Summary Calcitonin (CT), α-and β-CT gene-related peptide (CGRP), adrenomedullin (AM),
and amylin belong to the calcitonin family of peptides. Six or seven amino acid ring …

The calcitonin peptide family: what can we learn from receptor knock out and transgenic mice

W Born, JA Fischer - The calcitonin gene-related peptide family: form …, 2010 - Springer
This review focuses on the biological relevance of receptors of the calcitonin (CT) family of
peptides and respective ligands assessed in vivo through removal or overexpression of …

[HTML][HTML] The extreme N-terminus of the calcitonin-like receptor contributes to the selective interaction with adrenomedullin or calcitonin gene-related peptide

D Koller, W Born, K Leuthäuser, B Flühmann… - FEBS letters, 2002 - Elsevier
The calcitonin (CT)-like (CL) receptor is a CT gene-related peptide (CGRP) receptor or an
adrenomedullin (AM) receptor when co-expressed with receptor-activity-modifying proteins …

Aspartate69 of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and-2

LM Ittner, F Luessi, D Koller, W Born, JA Fischer… - Biochemical and …, 2004 - Elsevier
The calcitonin-like receptor (CLR) associated with receptor-activity-modifying proteins
(RAMP) 1 or-2 recognizes calcitonin gene-related peptide (CGRP) and adrenomedullin …

Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor

CM Koth, N Abdul-Manan, CA Lepre, PJ Connolly… - Biochemistry, 2010 - ACS Publications
The calcitonin gene-related peptide (CGRP) receptor is a heterodimer of two membrane
proteins: calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 …

Three receptor-activity-modifying proteins define calcitonin gene-related peptide or adrenomedullin selectivity of the mouse calcitonin-like receptor in COS-7 cells

K Husmann, W Born, JA Fischer, R Muff - Biochemical pharmacology, 2003 - Elsevier
Receptors for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are
heterodimeric complexes of the calcitonin-like receptor (CLR) together with associated …

Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: the contributions of novel receptor-activity-modifying proteins

W Born, JA Fischer, R Muff - Receptors and Channels, 2002 - Taylor & Francis
The discovery of receptor-activity-modifying proteins (RAMP) revealed a new principle for
the function of G protein-coupled receptors. The initially orphan calcitonin receptor-like …

[HTML][HTML] Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23–60 of the calcitonin receptor-like …

J Barwell, PS Miller, D Donnelly, DR Poyner - Peptides, 2010 - Elsevier
The calcitonin receptor-like receptor (CLR) acts as a receptor for the calcitonin gene-related
peptide (CGRP) but in order to recognize CGRP, it must form a complex with an accessory …

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

DR Poyner, PM Sexton, I Marshall, DM Smith… - Pharmacological …, 2002 - ASPET
The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin gene-related
peptides (CGRPs), and adrenomedullin. The first calcitonin receptor was cloned in 1991. Its …

[PDF][PDF] Identification of N-terminal receptor activity-modifying protein residues important for CGRP, adrenomedullin and amylin receptor function

T Qi, G Christopoulos, RJ Bailey… - Molecular …, 2008 - researchgate.net
Calcitonin-family receptors comprise calcitonin receptor-like receptor (CL) or calcitonin
receptor and receptor activity-modifying protein (RAMP) pairings. Calcitonin gene-related …