In animal experiments, positive effects have been reported with thrombolytic agents. Here
the emphasis has been on metastasis, and not so much on effects on the primary tumor …

Vitamin K-deficiency (either dietary or pharmacologically induced) has been reported to
reduce metastasis formation in some experimental tumor models, among which the Lewis …

2 Chahinian AP, Propert KJ, Ware JH, Zimmer B, Perry MC, Hirsh V, Skarin A, Kopel S,
Holland JF, Comis RL, Green MR. A radnomized trial of anticoagulation with warfarin and of …

1TQ ietters to the Editor because it is used commonly in patients with malignancy
complicated by deep vein thrombosis and can be given chronically on an outpatient basis …

5. Sakata K, Shirotani M, Yoshida H, Urano T, Takada Y, Takada A. Differential effects of
enalapril and nitrendipine on the fibrinolytic system in essential hypertension. Am Heart J …

Cells from some experimental tumors have been found to possess a peculiar procoagulant
activity, which directly activates coagulation factor X, independently of both the intrinsic and …

Vitamin Κ was discovered by Henrik Dam in 1929 in studies of sterol metabolism in chicks
fed fat-free diets (1). The antihemorrhagic fat-soluble agent was called vitamin Κ, Κ being …

To prevent venous and arterial thrombosis vitamin K antagonists (VKA) are the treatment of
choice for many indications. It is important to balance the benefits and the potential hazards …

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publication may be reproduced, stored in a retrieval systen, or transmitted,, in any form or by …

Evidence has accumulated that anticoagulants can reduce the incidence of metastases from
malignant tumours. Coumarin derivatives have been found most effective in various …