A diet enriched in PUFAs, in particular of the n-3 family, decreases adipose tissue mass and
suppresses development of obesity in rodents. Although several nuclear hormone receptors …

The bone marrow harbors a population of mesenchymal stem cells (MSCs) that possess the
potential to differentiate into bone, cartilage, and fat, and along other tissue pathways. To …

Peroxisome proliferator–activated receptor (PPAR)-γ is required for adipogenesis but is also
found in the cardiovascular system, where it has been proposed to oppose inflammatory …

White and brown adipose tissues, both present to some degree in all mammals, represent
counter actors in energy metabolism. One of the primary functions of white adipocytes is to …

Krox20 is a zinc finger-containing transcription factor that is abundantly expressed in
adipose tissue. However, its role in fat cell differentiation has not been established. In …

The differentiation of a preadipocyte into a mature adipocyte represents a fundamental
process in biology that requires a scripted program of transcriptional events leading to …

The peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of
adipogenesis and recruits coactivator proteins in response to ligand. However, the role of …

In addition to its role in energy storage, adipose tissue also accumulates cholesterol.
Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but …

Objective—Peroxisome proliferator-activated receptor gamma (PPARγ) is highly expressed
in macrophage-derived foam cells of atherosclerotic lesions, and its expression may have a …

Induction of brown adipocytes in white fat depots by adrenergic stimulation is a complex
genetic trait in mice that affects the ability of the animal to regulate body weight. An 80-fold …