We isolated multipotential mesenchymal stem cells (MSC) from human postnatal dermal
tissues. The isolated cells were expanded and maintained for over 100 population …

It is now over 10 years since the discovery of peroxisome proliferator activated receptor γ
(PPARγ) and its unique role in adipogenesis. The subsequent identification of PPARγ as the …

The nuclear receptor peroxisome proliferator–activated receptor-γ (PPARγ) is critically
required for adipogenesis. PPARγ exists as two isoforms, γ1 and γ2. PPARγ2 is the more …

Mutations in the XPD subunit of TFIIH give rise to human genetic disorders initially defined
as DNA repair syndromes. Nevertheless, xeroderma pigmentosum (XP) group D (XP-D) …

Scientific attention has been drawn to environmental factors that affect obesity and type II
diabetes. Previously, acute organotin toxicosis was reported to induce hyperglycemia …

The Src substrate associated in mitosis of 68 kDa (Sam68) is a KH-type RNA binding protein
that has been shown to regulate several aspects of RNA metabolism; however, its …

Background: Peroxisome proliferator-activated receptor γ (PPARγ) ligands improve human
hypertension. However, the mechanism and site of this effect remains unknown, confounded …

OBJECTIVES:: Changes in the hormonal milieu at the menopause are associated with an
increase in total adiposity and a more android pattern of fat distribution, with the latter …

PPARγ is a dominant regulator of fat cell differentiation. However, this nuclear receptor also
plays an important role in the differentiation of intestinal and other epithelial cell types. The …

In recent years, the thiazolidinediones (eg rosiglitazone, pioglitazone) have emerged as an
exciting novel class of therapeutic agent for the treatment of type 2 diabetes mellitus and the …