Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and β cell failure
JR Porter, TG Barrett - Journal of medical genetics, 2005 - jmg.bmj.com
Type 2 diabetes mellitus is caused by a combination of insulin resistance and β cell failure.
The polygenic nature of type 2 diabetes has made it difficult to study. Although many …
The polygenic nature of type 2 diabetes has made it difficult to study. Although many …
The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis
RL Kortum, DL Costanzo, J Haferbier… - … and cellular biology, 2005 - Taylor & Francis
Mitogen-activated protein kinase pathways are implicated in the regulation of cell
differentiation, although their precise roles in many differentiation programs remain elusive …
differentiation, although their precise roles in many differentiation programs remain elusive …
Mouse models of PPAR-γ deficiency: dissecting PPAR-γ's role in metabolic homoeostasis
SL Gray, E Dalla Nora… - Biochemical Society …, 2005 - portlandpress.com
The identification of humans with mutations in PPAR-γ (peroxisome-proliferator-activated
receptor-γ) has underlined its importance in the pathogenesis of the metabolic syndrome …
receptor-γ) has underlined its importance in the pathogenesis of the metabolic syndrome …
Gene expression profiling of orbital adipose tissue from patients with Graves' ophthalmopathy: a potential role for secreted frizzled-related protein-1 in orbital …
S Kumar, A Leontovich, MJ Coenen… - The Journal of Clinical …, 2005 - academic.oup.com
Context: The signs and symptoms of Graves' ophthalmopathy (GO) result from inflammation
and increased volume of the orbital adipose tissues and extraocular muscles. Objective: Our …
and increased volume of the orbital adipose tissues and extraocular muscles. Objective: Our …
Peroxisome proliferator‐activated receptor γ: the more the merrier?
CA Argmann, TA Cock, J Auwerx - European journal of clinical …, 2005 - Wiley Online Library
The consequence of activating the nuclear hormone receptor, peroxisome proliferator‐
activated receptor gamma (PPARγ), which coordinates adipocyte differentiation, validates …
activated receptor gamma (PPARγ), which coordinates adipocyte differentiation, validates …
[HTML][HTML] Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARγ ligand rosiglitazone
Overexpression of human epidermal growth factor receptor 2 (HER-2/neu) characterizes a
molecular subtype of breast cancer associated with poor clinical outcome. Preventive …
molecular subtype of breast cancer associated with poor clinical outcome. Preventive …
Gene expression analysis suggests that EBF-1 and PPARγ2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics
P Akerblad, R Månsson, A Lagergren… - Physiological …, 2005 - journals.physiology.org
Differentiation of multipotent mesenchymal stem cells into lipid-accumulating adipocytes is a
physiological process induced by transcription factors in combination with hormonal …
physiological process induced by transcription factors in combination with hormonal …
Retinoids potentiate peroxisome proliferator-activated receptor γ action in differentiation, gene expression, and lipid metabolic processes in developing myeloid cells
Nuclear hormone receptors have been shown to be important transcription factors for
regulating lipid metabolism in myeloid cells and were also implicated in differentiation …
regulating lipid metabolism in myeloid cells and were also implicated in differentiation …
Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β-cell function
Z Fatehi-Hassanabad, CB Chan - Nutrition & metabolism, 2005 - Springer
Background Optimal pancreatic β-cell function is essential for the regulation of glucose
homeostasis in both humans and animals and its impairment leads to the development of …
homeostasis in both humans and animals and its impairment leads to the development of …