PPARγ2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes

SE Schadinger, NLR Bucher… - American Journal …, 2005 - journals.physiology.org
Peroxisome proliferator-activated receptor-γ (PPARγ) is considered to be one of the master
regulators of adipocyte differentiation. PPARγ2 is abundantly expressed in mature …

[HTML][HTML] Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2

YK Lee, JE Park, M Lee, JP Hardwick - Liver research, 2018 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated
transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master …

Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression

S Yu, K Matsusue, P Kashireddy, WQ Cao… - Journal of Biological …, 2003 - ASBMB
Peroxisome proliferator activated-receptor (PPAR) isoforms, α and γ, function as important
coregulators of energy (lipid) homeostasis. PPARα regulates fatty acid oxidation primarily in …

Increased expression of PPARγ in high fat diet-induced liver steatosis in mice

M Inoue, T Ohtake, W Motomura, N Takahashi… - Biochemical and …, 2005 - Elsevier
The present study was performed to examine a hypothesis that peroxisome proliferator-
activated receptor γ (PPARγ) is implicated in high fat diet-induced liver steatosis. Mice were …

PPARα activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes

U Edvardsson, A Ljungberg, D Lindén… - Journal of lipid …, 2006 - ASBMB
Adipose differentiation-related protein (ADRP) is a lipid droplet-associated protein that is
expressed in various tissues. In mice treated with the peroxisome proliferator-activated …

[PDF][PDF] Peroxisome proliferator‐activated receptor‐δ induces insulin‐induced gene‐1 and suppresses hepatic lipogenesis in obese diabetic mice

X Qin, X Xie, Y Fan, J Tian, Y Guan, X Wang… - …, 2008 - Wiley Online Library
Primary nonalcoholic fatty liver disease is one of the most common forms of chronic liver
diseases and is associated with insulin‐resistant states such as diabetes and obesity …

Aberrant hepatic expression of PPARγ2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis

YL Zhang, A Hernandez-Ono, P Siri, S Weisberg… - Journal of Biological …, 2006 - ASBMB
Insulin-resistant apoB/BATless mice have hypertriglyceridemia because of increased
assembly and secretion of very low density apolipoprotein B (apoB) and triglycerides …

PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice

Y Wang, T Nakajima, FJ Gonzalez… - International journal of …, 2020 - mdpi.com
Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis.
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …

Up-regulation of peroxisome proliferator-activated receptors (PPAR-α) and PPAR-γ messenger ribonucleic acid expression in the liver in murine obesity: troglitazone …

RA Memon, LH Tecott, K Nonogaki, A Beigneux… - …, 2000 - academic.oup.com
Peroxisome proliferator-activated receptors (PPARs) are transcription factors that play an
important role in the regulation of genes involved in lipid utilization and storage, lipoprotein …

PPARα governs glycerol metabolism

D Patsouris, S Mandard, PJ Voshol… - The Journal of …, 2004 - Am Soc Clin Investig
Glycerol, a product of adipose tissue lipolysis, is an important substrate for hepatic glucose
synthesis. However, little is known about the regulation of hepatic glycerol metabolism. Here …