The principal abnormalities of the metabolic syndrome are abdominal obesity, atherogenic
dyslipidemia, hypertension, insulin resistance, inflammation, and prothrombotic states. This …

A large number of physiological processes in the adult liver are regulated by nuclear
receptors that require heterodimerization with retinoid X receptors (RXRs). In this study, we …

Retinoid X receptors (RXRs) have been implicated in a diversity of cellular processes
ranging from cellular proliferation to lipid metabolism. These pleiotropic effects stem not only …

A common feature of many metabolic pathways is their control by retinoid X receptor (RXR)
heterodimers. Dysregulation of such metabolic pathways can lead to the development of …

Activated by retinoids, metabolites of vitamin A, the retinoic acid receptors (RARs) and the
retinoid X receptors (RXRs) play important roles in a wide variety of biological processes …

Retinoids, naturally-occurring vitamin A derivatives, regulate metabolism by activating
specific nuclear receptors, including the retinoic acid receptor (RAR) and the retinoid X …

The retinoid X receptor and its ligands: versatile regulators of metabolic function, cell
differentiation and cell death Page 1 INTRODUCTION The concept of retinoids as a distinct …

Obesity and type II diabetes are closely related metabolic diseases with an increasing
incidence worldwide. No clear-cut pharmacological treatment for these complex metabolic …

As the promiscuous partner of heterodimeric associations, retinoid X receptors (RXRs) play
a key role within the Nuclear Receptor (NR) superfamily. Some of the heterodimers …

Vitamin A signaling occurs through nuclear receptors recognizing diverse forms of retinoic
acid (RA). The retinoic acid receptors (RARs) bind all‐trans RA and its 9‐cis isomer (9‐cis …