Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into several
distinct lineages. Two key transcription factors, Runx2 and peroxisome proliferator–activated …

Regulating the switch between proliferation and differentiation of mesenchymal stem cells is
critical for the development of normal tissues, and the prevention of tumors. How …

Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade
of activated transcription factors and epigenetic modifications that drive gene transcription …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

The osteoblastic and adipocytic lineages arise from mesenchymal stem cells (MSCs), but
few regulators of self-renewal and early cell-fate decisions are known. Here, we show that …

Abstract Background Mesenchymal stem cells (MSCs) are multipotent stem cells that are
able to differentiate into several cell types, including cartilage, fat, and bone. As a common …

Osteoblasts and adipocytes differentiate from common pleiotropic mesenchymal stem cells
under transcriptional controls by numerous factors and multiple intracellular signalings …

Mesenchymal stem cells (MSCs) are multipotent cells that represent a promising source for
regenerative medicine. MSCs are capable of osteogenic, chondrogenic, adipogenic and …

Osteoblasts and adipocytes differentiate from a common precursor, the pluripotent
mesenchymal stem cell (MSC) found in bone marrow (BMSC) and adipose tissue (AD …

TAZ (transcriptional coactivator with PDZ-binding motif) is a transcriptional modulator that
regulates mesenchymal stem cell differentiation. It stimulates osteogenic differentiation while …