Cyclin-dependent kinase 5 (cdk5) is a member of the cyclin-dependent kinase family whose
activity is localized mainly to postmitotic neurons attributable to the selective expression of …

Many neurological disorders like Parkinson's and Alzheimer's disease, amyotrophic lateral
sclerosis (ALS) or stroke have in common a definite loss of CNS neurons due to apoptotic or …

Abstract Cyclin-dependent kinase 5 (Cdk5) is a member of the cyclin-dependent kinase
family that is mostly seen in neurons, does not vary with cell cycle, and is activated in many …

Accumulating evidence indicates that deregulation of cyclin-dependent kinase 5 (Cdk5)
activity is associated with apoptosis in various neurodegenerative disease models …

Abstract Cyclin‐dependent kinase 5 (cdk5) is a serine/threonine kinase activated by
associating with its neuron‐specific activators p35 and p39. Analysis of cdk5−/− and p35 …

J. Neurochem.(2010) 115, 1309–1321. Abstract Cyclin‐dependent kinase (Cdk) 5 is a
proline‐directed Ser/Thr protein kinase that functions mainly in neurons and is activated by …

Previous studies suggested that pro-apoptotic stimuli may trigger a fatal reactivation of cell
cycle elements in postmitotic neurons. Supporting this hypothesis, small molecule inhibitors …

Dysregulation of cyclin‐dependent kinase 5 (Cdk5) by cleavage of its activator p35 to p25 by
calpain is involved in the neuronal cell death observed in neurodegenerative disorders …

While the requirement of CDKs in cell cycle control is well established, the participation of
CDK family members in other important biological processes are now beginning to be …

The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase
that plays important roles in many cellular functions including cell motility and survival. The …