Cell culture models have been developed to study commitment and subsequent
differentiation of preadipocytes into adipocytes. Bone morphogenetic protein 4 commits …

Gregoire, Francine M., Cynthia M. Smas, and Hei Sook Sul. Understanding Adipocyte
Differentiation. Physiol. Rev. 78: 783–809, 1998.—The adipocyte plays a critical role in …

Excessive caloric intake without a rise in energy expenditure promotes adipocyte
hyperplasia and adiposity. The rise in adipocyte number is triggered by signaling factors that …

The formation of adipocytes from precursor stem cells involves a complex and highly
orchestrated programme of gene expression. Our understanding of the basic network of …

Improved knowledge of all aspects of adipose biology will be required to counter the
burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the …

Recent advances regarding the biology of adipose tissue have demonstrated that white
adipose tissue (WAT) plays a central role in the regulation of energy balance and acts as a …

The raison d'etre of the adipocyte is to store energy (in the form of triacylglycerol) for use
during periods of caloric insufficiency. Adipocytes first appear late in fetal development …

Significant advances have been made recently toward understanding the molecular events
that regulate adipocyte differentiation. In vitromodels of adipogenesis, such as the 3T3-L1 …

A detailed understanding of the processes governing adipose tissue formation will be
instrumental in combating the obesity epidemic. Much progress has been made in the last …

The adipose cell is now known to play a complex role in energy homeostasis, energy
storage and signaling to other tissues concerning the state of energy balance. The past few …