The many faces of PPARγ

M Lehrke, MA Lazar - Cell, 2005 - cell.com
In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular
disease, the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) has …

Peroxisome proliferator‐activated receptor‐γ: too much of a good thing causes harm

TA Cock, SM Houten, J Auwerx - EMBO reports, 2004 - embopress.org
The nuclear receptor peroxisome proliferator‐activated receptor‐γ (PPARγ) helps to
translate 'what you eat'into 'what you are'because it allows dietary fatty acids (PPARγ …

PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism

R Walczak, P Tontonoz - Journal of lipid research, 2002 - ASBMB
The nuclear receptor PPARγ is a central regulator of adipose tissue development and an
important modulator of gene expression in a number of specialized cell types including …

PPARγ, 10 years later

MA Lazar - Biochimie, 2005 - Elsevier
It is now over 10 years since the discovery of peroxisome proliferator activated receptor γ
(PPARγ) and its unique role in adipogenesis. The subsequent identification of PPARγ as the …

Fat and beyond: the diverse biology of PPARγ

P Tontonoz, BM Spiegelman - Annu. Rev. Biochem., 2008 - annualreviews.org
The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

The nuclear receptor PPARγ-bigger than fat

SA Kliewer, TM Willson - Current opinion in genetics & development, 1998 - Elsevier
Work reported over the past year has provided insights into the mechanisms whereby ligand
activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) …

PPARγ, the ultimate thrifty gene

J Auwerx - Diabetologia, 1999 - Springer
The peroxisome proliferator-activated receptor gamma (PPAR γ) quickly evolved over the
last decade from a new orphan receptor to one of the best characterized nuclear receptors …

Peroxisome proliferator‐activated receptor γ: the more the merrier?

CA Argmann, TA Cock, J Auwerx - European journal of clinical …, 2005 - Wiley Online Library
The consequence of activating the nuclear hormone receptor, peroxisome proliferator‐
activated receptor gamma (PPARγ), which coordinates adipocyte differentiation, validates …

Peroxisome proliferator-activated receptor-γ: a versatile metabolic regulator

S Rocchi, J Auwerx - Annals of medicine, 1999 - Taylor & Francis
The peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear receptor that controls
the expression of a large array of genes involved in adipocyte differentiation, lipid storage …

PPARγ and human metabolic disease

RK Semple, VKK Chatterjee… - The Journal of clinical …, 2006 - Am Soc Clin Investig
The nuclear receptor family of PPARs was named for the ability of the original member to
induce hepatic peroxisome proliferation in mice in response to xenobiotic stimuli. However …