Influence of brain injury on early posttraumatic bone metabolism

OA Trentz, AE Handschin, L Bestmann… - Critical care …, 2005 - journals.lww.com
Background: Various clinical studies and observations demonstrate enhanced osteogenesis
in patients sustaining traumatic brain injury. It is presumed that the induction of this process …

Humoral factors enhance fracture-healing and callus formation in patients with traumatic brain injury

D Cadosch, OP Gautschi, M Thyer, S Song, AP Skirving… - JBJS, 2009 - journals.lww.com
Background: Scientific evidence is mounting for an association between traumatic brain
injury and enhanced osteogenesis. The aim of this study was to correlate the in vitro …

Serum‐mediated osteogenic effect in traumatic brain‐injured patients

OP Gautschi, D Cadosch, SP Frey… - ANZ journal of …, 2009 - Wiley Online Library
Background: Patients with a traumatic brain injury (TBI) and bone fractures often show an
enhanced fracture healing, as well as an increased incidence of heterotopic ossifications …

Post-traumatic dynamic change of carboxyterminal propeptide of type I procollagen, alkaline phosphatase and its isoenzymes as predictors for enhanced …

R Wildburger, N Zarkovic, H Dobnig, W Petek… - Research in …, 1994 - Springer
Patients suffering from severe head injury and fractures of long bones or large joints often
show enhanced osteogenesis, with hypertrophic callus formation and/or heterotopic …

Reduced collagen degradation in polytraumas with traumatic brain injury causes enhanced osteogenesis

J Andermahr, A Elsner, AE Brings, T Hensler… - Journal of …, 2006 - liebertpub.com
Patients with traumatic brain injury (TBI) and skeletal injuries have increased rates of
excessive bone healing (EH= hypertrophic callus formation and/or heterotopic ossification) …

Bone biomarkers in patients with chronic traumatic spinal cord injury

H Sabour, AN Javidan, S Latifi, B Larijani, F Shidfar… - The Spine Journal, 2014 - Elsevier
Background context Bone loss after spinal cord injury (SCI) occurs because of pathologic
changes in osteoblastic and osteoclastic activities due to mechanical unloading. Some …

Functional and proteomic analysis of serum and cerebrospinal fluid derived from patients with traumatic brain injury: a pilot study

D Cadosch, M Thyer, OP Gautschi… - ANZ journal of …, 2010 - Wiley Online Library
Background: An enhanced fracture healing response has been reported in patients with
traumatic brain injury (TBI). This has been attributed to circulating humoral factors that are …

Depressed osteoblast activity and increased osteocyte necrosis after closed bone fracture and hemorrhagic shock

MW Wichmann, SP Arnoczky, CM DeMaso… - Journal of Trauma …, 1996 - journals.lww.com
Background Although bone fracture and hemorrhagic shock are frequent complications in
trauma patients, it remains unknown whether hemorrhagic shock after bone fracture …

From brain to bone: evidence for the release of osteogenic humoral factors after traumatic brain injury

AM Toffoli, OP Gautschi, SP Frey, L Filgueira… - Brain Injury, 2008 - Taylor & Francis
Primary objective: The aetiology of the increased osteogenesis associated with severe
traumatic brain injury (TBI) remains incompletely understood. The purpose of this article is to …

Bone physiology and therapeutics in chronic critical illness

MA Via, EJ Gallagher… - Annals of the New York …, 2010 - Wiley Online Library
Modern medical practices allow patients to survive acute insults and be sustained by
machinery and medicines for extended periods of time. We define chronic critical illness as a …