Pontin and Reptin previously were identified as nuclear β-catenin interaction partners that
antagonistically modulate β-catenin transcriptional activity. In this study, Hint1/PKCI, a …

Wnt signaling is essential during development while deregulation of this pathway frequently
leads to the formation of various tumors including colorectal carcinomas. A key component …

In Wnt‐stimulated cells, β‐catenin becomes stabilized in the cytoplasm, enters the nucleus
and interacts with HMG box transcription factors of the lymphoid‐enhancing factor‐1 (LEF …

Duplin binds to β-catenin and inhibits the Wnt signaling pathway, thereby leading to
repression of the β-catenin-mediated transactivation and Xenopus axis formation. To find an …

Hint1 is a member of the evolutionarily conserved family of histidine triad proteins that acts
as a haplo-insufficient tumor suppressor inducing spontaneous tumor formation in Hint+ …

The Zic transcription factors play critical roles during embryonic development. Mutations in
the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still …

A key effector of the canonical Wnt pathway is β-catenin, which binds to TCF/LEF factors to
promote the transcription of Wnt target genes. In the absence of Wnt stimulation, β-catenin is …

β-Catenin is efficiently phosphorylated by glycogen synthase kinase-3β in the Axin complex
in the cytoplasm, resulting in the down-regulation. In response to Wnt, β-catenin is stabilized …

The histidine triad (HIT) protein Hint has been found to associate with mammalian Cdk7, as
well as to interact both physically and genetically with the budding yeast Cdk7 homologue …

Canonical Wnt signaling regulates many aspects of cellular physiology and tissue
homeostasis during development and in adult organisms. In molecular terms, stimulation by …