Ataxia telangiectasia (AT) is a rare human disease characterized by extreme cellular
sensitivity to radiation and a predisposition to cancer, with a hallmark of onset in early …

Ataxia telangiectasia (AT) has long intrigued the biomedical research community owing to
the spectrum of defects that are characteristic of the disease, including neurodegeneration …

Ataxia-telangiectasia mutated (ATM) is the product of the gene mutated in the human
genetic disorder ataxia-telangeictasia (AT). It is a 370 kDa protein that is a member of the …

First described over 80 years ago, ataxia-telangiectasia (AT) was defined as a clinical entity
50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer …

In 1988, the gene responsible for the autosomal recessive disease ataxia-telangiectasia
(AT) was localized to 11q22. 3-23.1. It was eventually cloned in 1995. Many independent …

Ataxia-telangiectasia (AT) is an autosomal recessive disorder involving cerebellar
degeneration, immunodeficiency, chromosomal instability, radiosensitivity and cancer …

Ataxia-telangiectasia (AT) is an autosomal recessive inherited disease caused by mutational
inactivation of the ATM gene. It is a multisystemic disease, characterized by progressive …

Ataxia telangiectasia (AT) is a rare neurodegenerative, autosomal recessive disorder
characterized by chromosome instability, radiosensitivity, immunodeficiency and a …

Ataxia-telangiectasia (AT) is an autosomal recessive multi-system disorder caused by
mutation in the ataxia-telangiectasia mutated gene (ATM). ATM is a large serine/threonine …

DNA damage is one of the most acute threats to cellular homeostasis and life. The cell
responds to such damage by activating a vast array of responses, ranging from DNA repair …