Aim: To study the mechanisms by which N‐demethyl‐clarithromycin (NDC) induces human
cervical cancer HeLa cell apoptosis in vitro. Methods: The viability of N‐demethyl …

Although it was discovered more than 70 years ago that caloric restriction (CR) extends the
life span of rodents, the molecular basis of CR has remained obscure. Recently, NAD …

Many current drugs increase the average lifespan by preventing fatal diseases or by slowing
down the progressive degenerative diseases that increase mortality. The existing strategies …

Histone deacetylases perform an important role in the regulation of transcription by
modifying the histone components of chromatin. This imparts specific restrictions to …

While at present there is no scientific consensus on the reasons for cellular and organismal
ageing-or indeed on a comprehensive definition for ageing-scientific efforts to unravel the …

DNA in eukaryotes is arranged into higher order structures termed chromatin. Chromatin
poses an obstacle for gene transcription because it is not readily accessible to DNA binding …

The exact contribution of the sirtuin family of NAD+-dependent histone deacetylases to
longevity in metazoans is, at present, not completely understood but nonetheless regarded …

Aging is a complex process that influences many aspects of our lives, yet little is known
about the molecular pathways that regulate its progression. To understand the mechanisms …

(57) ABSTRACT A mouse model for mammalian aging is disclosed. In one embodiment, the
invention comprises a mouse having a genomic mutation in the exonuclease domain II …

Sirtuins are NAD-dependent protein deacetylases found in organisms ranging from bacteria
to humans that share sequence homology with the yeast transcriptional regulator Sir2. In …