The mechanism employed by DNA tumor viruses to inhibit p53-dependent transcription is poorly understood. Here we describe a new paradigm for human papillomavirus (HPV) E6 …
Gene expression is dependent on the ability of sequence specific DNA-binding proteins to regulate the transcription of target genes in a coordinated fashion. This is accomplished, in …
CL Brooks, W Gu - Gene Expression and Regulation, 2006 - Springer
The p53 tumor suppressor acts as a potent transcription factor in response to bombardment by a variety of cellular stresses. Its importance in maintaining genomic stability and exerting …
Abstract p53 is the most commonly mutated tumor suppressor gene in human cancers. Activation of p53 maintains the genomic integrity and protects the organism against the …
The Epstein-Barr virus (EBV) carrier state is widespread in humans. Primary infection can cause infectious mononucleosis (IM) that presents with variable clinical severity, but almost …
The work presented in this thesis concentrates on the functional consequences of acetylation upon the retinoblastoma tumour suppressor protein (pRb), the activity of which is …
Characterization of the tetrameric monocytic leukemia zinc finger protein complex Page 1 Characterization of the tetrameric monocytic leukemia zinc finger protein complex Mukta Ullah …
The work described in this dissertation utilizes molecular biological techniques to address a number of key questions relating to the mechanisms of Huntington's disease pathogenesis …