Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has
been suggested to modulate p53-dependent functions including DNA damage-induced cell …

SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor
Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in …

The cellular NAD+/NADH level controls Sir2 (silent information regulator 2) deacetylase
activity in regulating aging in lower species. Much work has been put forth to identify ways to …

DNA damage-induced acetylation of p53 protein leads to its activation and either growth
arrest or apoptosis. We show here that the protein product of the gene hSIR2 SIRT1, the …

Human SIRT1 is an NAD+-dependent deacetylase protein that plays a role in cell
death/survival, senescence, and endocrine signaling. While its substrates, including p53 …

The deacetylase SIRT1 regulates multiple biological processes including cellular
metabolism and aging. Importantly, SIRT1 can also inactivate the p53 tumor suppressor via …

In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin
silencing, longevity, and genome stability. Here we mutated the Sirt1 gene, a homolog of …

Members of the evolutionarily conserved silent information regulator 2 (Sir2) protein family
are nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases. In yeast …

SIRT1 is a conserved NAD-dependent deacetylase that regulates life span in accord with
nutritional provision. In mammalian cells, SIRT1 also down-regulates stress-induced p53 …

SIRT1, an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase, protects cells
from stress-induced apoptosis, and its orthologues delay aging in lower eukaryotes. SIRT1 …