Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms.
In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 …

Sir2 NAD-dependent deacetylases connect transcription, metabolism, and aging. Increasing
the dosage or activity of Sir2 extends life span in yeast, worms, and flies and promotes fat …

Abstract Aims/hypothesis Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of
glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be …

The Sir2 (silent information regulator 2) family of NAD‐dependent deacetylases regulates
aging and longevity across a wide variety of organisms, including yeast, worms, and flies. In …

The lifespan of the nematode, Caenorhabditis elegans, can be extended by mutations
affecting components of the insulin-like growth factor (IGF) signaling cascade or by …

We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been
generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for …

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast,
flies, and worms. Mammals have seven Sir2 homologs (SIRT1–7). We show that SIRT4 is a …

Abstract Sirtuin 6 (Sirt6), a chromatin associated class III deacetylase, controls whole-body
energy homeostasis and has a critical role in glucose-stimulated insulin secretion (GSIS) in …

The protein deacetylase SIRT1, and its activator resveratrol, exert beneficial effects on
glucose metabolism. Different SIRT1 targets have been identified, including PTP1B, AMPK …

NAD+-dependent Sir2 family deacetylases and insulin signaling pathway are both
conserved across species to regulate aging process. The interplay between these two …