BACKGROUND: Rotavirus gastroenteritis, which causes substantial infant mortality and
morbidity worldwide, is a vaccine-preventable disease. The purpose of this study was to …

BACKGROUND. Rotavirus is the leading cause of dehydrating acute gastroenteritis in
infants worldwide. Previous studies of a live pentavalent human-bovine reassortant rotavirus …

Background: Premature infants seem to be at greater risk of hospitalization from rotavirus
gastroenteritis than term infants. Safety and efficacy of the pentavalent human-bovine (WC3) …

Rotavirus gastroenteritis is a disease that causes significant morbidity and mortality
worldwide in infants and children. The recent availability of efficacious rotavirus vaccines …

OBJECTIVES: To investigate safety, efficacy, and immunogenicity of live quadrivalent
rotavirus vaccine (QRV) containing human-bovine (WC3) reassortant rotavirus serotypes …

Twenty-five years passed between the discovery of the parent strain (WC3) of the
pentavalent human-bovine reassortant rotavirus vaccine (PRV) in 1981 and the licensure of …

Background Rotavirus is a leading cause of childhood gastroenteritis and death worldwide.
Methods We studied healthy infants approximately 6 to 12 weeks old who were randomly …

The strategy of decreasing the morbidity and mortality associated with rotavirus
gastroenteritis through vaccination is supported by studies demonstrating that wild-type …

The safety and immunogenicity of an orally administered, live rotavirus vaccine comprised of
four strains, each with a titer of 105.3 or 105.8 pfu, and each having 10 genes from the UK …

Background: A live pentavalent rotavirus vaccine (PRV) containing 5 human-bovine (WC3)
reassortants expressing human serotypes G1, G2, G3, G4 and P1A [8] was evaluated in a …