Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
A common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF)
gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated …
gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is associated …
BDNF variant linked to anxiety‐related behaviors
K Hashimoto - Bioessays, 2007 - Wiley Online Library
Brain-derived neurotrophic factor (BDNF) is the most-abundant neurotrophin in the brain. In
mammals, it is synthesized as a precursor called proBDNF, which is proteolytically cleaved …
mammals, it is synthesized as a precursor called proBDNF, which is proteolytically cleaved …
Impact of genetic variant BDNF (Val66Met) on brain structure and function
ZY Chen, K Bath, B McEwen… - Growth Factors and …, 2008 - Wiley Online Library
A common single‐nucleotide polymorphism in the human brain‐derived neurotrophic factor
(BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is …
(BDNF) gene, a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met), is …
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction
A common single-nucleotide polymorphism (SNP) in the human brain-derived neurotrophic
factor (BDNF) gene results in a Val66Met substitution in the BDNF prodomain region. This …
factor (BDNF) gene results in a Val66Met substitution in the BDNF prodomain region. This …
A genetic variant BDNF polymorphism alters extinction learning in both mouse and human
Mouse models are useful for studying genes involved in behavior, but whether they are
relevant to human behavior is unclear. Here, we identified parallel phenotypes in mice and …
relevant to human behavior is unclear. Here, we identified parallel phenotypes in mice and …
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants
H Yu, DD Wang, Y Wang, T Liu, FS Lee… - Journal of …, 2012 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) plays important roles in cell survival, neural
plasticity, learning, and stress regulation. However, whether the recently found human BDNF …
plasticity, learning, and stress regulation. However, whether the recently found human BDNF …
Variant brain‐derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorder
H Frielingsdorf, KG Bath, F Soliman… - Annals of the New …, 2010 - Wiley Online Library
Recently, a common single nucleotide polymorphism (SNP) has been identified in the gene
encoding brain‐derived neurotrophic factor (BDNF). The variant BDNFMet has been shown …
encoding brain‐derived neurotrophic factor (BDNF). The variant BDNFMet has been shown …
Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory
The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is
associated with reduced activity-dependent BDNF release and increased risk for anxiety …
associated with reduced activity-dependent BDNF release and increased risk for anxiety …
Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like …
BACKGROUND: Most anxiety and depressive disorders are twice as common in women
compared with men, and the sex difference in prevalence typically emerges during …
compared with men, and the sex difference in prevalence typically emerges during …
New insights into BDNF function in depression and anxiety
K Martinowich, H Manji, B Lu - Nature neuroscience, 2007 - nature.com
The'neurotrophin hypothesis of depression'is based largely on correlations between stress
or antidepressant treatment and down-or upregulation, respectively, of brain-derived …
or antidepressant treatment and down-or upregulation, respectively, of brain-derived …