The mammalian target of rapamycin (mTOR) is a large and highly conserved kinase that
integrates growth factor stimulation, energy and nutrient availability to modulate translation …

Pleiotrophin (PTN) is an 18 kDa growth factor that has high affinity for heparin and together
with midkine form a family of structurally related heparin binding growth factors. Screening of …

Phosphorylation of tyrosine residues by protein tyrosine kinases mediates numerous cellular
processes. Deregulated tyrosine phosphorylation underlies constitutive activation of …

The fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), results from
the chromosome translocation t (2; 5)(p23; q25) and is present in 50–70 percent of …

Hsp90 inhibitors are currently in clinical trials for cancer therapy based on their ability to
promote proteasomal degradation of oncogenic protein kinases and nuclear receptors …

Abstract Plasminogen activator inhibitor (PAI-1) is an anticancer agent that inhibits plasmin
driven proteolysis, limiting angiogenesis and metastasis. In low concentrations it could …

Abstract The t (2; 5) chromosomal translocation occurs in anaplastic large-cell lymphoma
arising from activated T lymphocytes. This genomic rearrangement generates the …

The mammalian target of rapamycin (mTOR) kinase is positioned at the juncture of several
pathways regulating cell growth and proliferation. It is the downstream effector of the …

Germinal centers (GCs) represent the main sites for the generation of high-affinity, class-
switched antibodies during T cell-dependent antibody responses. To study gene function …

The oncogenic fusion tyrosine kinase, NPM/ALK, induces cellular transformation in
anaplastic large cell lymphomas (ALCL) carrying the t (2; 5) chromosomal translocation …