The source of aldosterone in 30–40% of patients with primary hyperaldosteronism (PA) is
unilateral aldosterone-producing adenoma (APA). The mechanisms causing elevated …

Context: The mechanisms driving steroid production in aldosterone-producing adenomas
(APAs) are poorly defined. However, previous studies have shown that steroid production in …

Background Primary aldosteronism (PA) is the most common form of endocrine
hypertension affecting∼ 8–10% of hypertensive subjects. Aldosterone production in PA …

Objective The investigation of expression and functional relevance of G-protein coupled
receptors in primary aldosteronism (PA) by molecular and clinical studies. Patients and …

Context: Excess production of aldosterone or cortisol has profound effects on cardiovascular
function and impacts other major organ systems. The mechanisms leading to the …

Context: Primary aldosteronism (PAL) is the most frequent cause of secondary arterial
hypertension. In PAL, aldosterone production is chronic, excessive, and autonomous …

Aldosterone-producing adenoma (APA) cause primary aldosteronism—the most frequent
form of secondary hypertension. Somatic mutations in genes coding for ion channels and …

Primary aldosteronism (PA) is the most common form of secondary hypertension with an
estimated prevalence of~ 10% in referred patients. PA occurs as a result of a dysregulation …

The great majority of the cases clinically diagnosed as primary aldosteronism (PA) have
been caused by aldosterone‐producing adenoma (APA) or idiopathic hyperaldosteronism …

Aldosterone-producing adenomas (APAs) are a common cause of arterial hypertension, but
the underlying molecular mechanisms are unknown, although a transcriptional modulation …