The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expression is associated with the
lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from at (2; 5) …
lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from at (2; 5) …
Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
M Kasprzycka, M Marzec, X Liu… - Proceedings of the …, 2006 - National Acad Sciences
The mechanisms of malignant cell transformation mediated by the oncogenic, chimeric
nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) tyrosine kinase remain only …
nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) tyrosine kinase remain only …
NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma
A Galietta, RH Gunby, S Redaelli… - Blood, The Journal …, 2007 - ashpublications.org
The oncogenic fusion tyrosine kinase nucleophosmin/anaplastic lymphoma kinase
(NPM/ALK) induces cellular transformation in anaplastic large-cell lymphomas (ALCLs) …
(NPM/ALK) induces cellular transformation in anaplastic large-cell lymphomas (ALCLs) …
The pathobiology of the oncogenic tyrosine kinase NPM-ALK: a brief update
R Lai, RJ Ingham - Therapeutic advances in hematology, 2013 - journals.sagepub.com
Extensive research has been carried out in the past two decades to study the pathobiology
of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which is an oncogenic fusion …
of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which is an oncogenic fusion …
Identification of NPM-ALK interacting proteins by tandem mass spectrometry
DK Crockett, Z Lin, KSJ Elenitoba-Johnson, MS Lim - Oncogene, 2004 - nature.com
Constitutive overexpression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is a
key oncogenic event in anaplastic large-cell lymphomas with the characteristic …
key oncogenic event in anaplastic large-cell lymphomas with the characteristic …
Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation
M Chikamori, J Fujimoto, N Tokai-Nishizumi… - Oncogene, 2007 - nature.com
Abstract The t (2; 5) chromosomal translocation occurs in anaplastic large-cell lymphoma
arising from activated T lymphocytes. This genomic rearrangement generates the …
arising from activated T lymphocytes. This genomic rearrangement generates the …
Nucleophosmin–anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling …
RY Bai, T Ouyang, C Miething… - Blood, The Journal …, 2000 - ashpublications.org
More than half of anaplastic large-cell lymphomas (ALCLs) have a chromosomal
translocation t (2; 5) that leads to the expression of a hybrid protein composed of the …
translocation t (2; 5) that leads to the expression of a hybrid protein composed of the …
NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma
V Leventaki, E Drakos, LJ Medeiros… - Blood, The Journal …, 2007 - ashpublications.org
Anaplastic large-cell lymphoma (ALCL) frequently carries the t (2; 5)(p23; q35), resulting in
aberrant expression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). We show …
aberrant expression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). We show …
What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis?
SD Turner, DR Alexander - Leukemia, 2005 - nature.com
The nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is generated as at (2; 5)
chromosomal breakpoint product, typically in CD30+ anaplastic large cell lymphomas …
chromosomal breakpoint product, typically in CD30+ anaplastic large cell lymphomas …
Downregulation of NPM-ALK by siRNA causes anaplastic large cell lymphoma cell growth inhibition and augments the anti cancer effects of chemotherapy in vitro
FY Hsu, Y Zhao, WF Anderson, PB Johnston - Cancer investigation, 2007 - Taylor & Francis
The fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), results from
the chromosome translocation t (2; 5)(p23; q25) and is present in 50–70 percent of …
the chromosome translocation t (2; 5)(p23; q25) and is present in 50–70 percent of …