The mineralocorticoid aldosterone, mainly produced by the adrenal gland, is essential for
life, but an abnormally excessive secretion causes severe pathological effects including …

Potassium and angiotensin II are the main stimulators of aldosterone secretion from the
adrenal cortex. As potassiuminduced in vivo gene regulation in the adrenal cortex has not …

Primary aldosteronism (PA) is the most common form of endocrine hypertension. This study
was to investigate the gene expression profile in PA adrenal glands and normal controls …

Evidence for the dysregulation of aldosterone synthesis in cardiovascular pathophysiology
has renewed interest in the control of its production. Cellular mechanisms by which …

The renal aldosterone-sensitive distal tubule (ASDT) is crucial for sodium reabsorption and
blood pressure regulation. The ASDT consists of the late distal convoluted tubule (DCT2) …

We recently identified hundreds of transcripts with differential expression in rat zona
glomerulosa (zG) and zona fasciculata. Although the genes up-regulated in the zG may be …

Early aldosterone up-regulated genes: New pathways for renal disease? Background The
use of aldosterone antagonists has important beneficial effects on the progression of renal …

Transcription regulatory genes are crucial modulators of cell physiology and metabolism
whose intracellular levels are tightly controlled to respond to extracellular stimuli. We studied …

The mineralocorticoid aldosterone is a major regulator of Na+ and acid-base balance and
control of blood pressure. Although the long-term effects of aldosterone have been …

Abstract Angiotensin-II (Ang-II) regulates adrenal steroid production and gene transcription
through several signaling pathways. Changes in gene transcription occur within minutes …