Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway
M Marzec, M Kasprzycka, X Liu, M El-Salem, K Halasa… - Oncogene, 2007 - nature.com
The mechanisms of cell transformation mediated by the nucleophosmin (NPM)/anaplastic
lymphoma kinase (ALK) tyrosine kinase are only partially understood. Here, we report that …
lymphoma kinase (ALK) tyrosine kinase are only partially understood. Here, we report that …
Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
M Kasprzycka, M Marzec, X Liu… - Proceedings of the …, 2006 - National Acad Sciences
The mechanisms of malignant cell transformation mediated by the oncogenic, chimeric
nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) tyrosine kinase remain only …
nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) tyrosine kinase remain only …
Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf
M Marzec, M Kasprzycka, X Liu, PN Raghunath… - Oncogene, 2007 - nature.com
The mechanisms of cell transformation mediated by the highly oncogenic, chimeric
NPM/ALK tyrosine kinase remain only partially understood. Here we report that cell lines …
NPM/ALK tyrosine kinase remain only partially understood. Here we report that cell lines …
Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase–positive anaplastic large cell …
F Vega, LJ Medeiros, V Leventaki, C Atwell… - Cancer research, 2006 - AACR
Anaplastic lymphoma kinase (ALK)–positive anaplastic large cell lymphoma (ALCL)
frequently carries the t (2; 5)(p23; q35) resulting in aberrant expression of chimeric …
frequently carries the t (2; 5)(p23; q35) resulting in aberrant expression of chimeric …
Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G1 cell cycle arrest and …
The anaplastic lymphoma kinase (ALK) is an oncogene product involved in hematopoietic
and non-hematopoietic malignancies. Recent studies have demonstrated that …
and non-hematopoietic malignancies. Recent studies have demonstrated that …
The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expression is associated with the
lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from at (2; 5) …
lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from at (2; 5) …
The pathobiology of the oncogenic tyrosine kinase NPM-ALK: a brief update
R Lai, RJ Ingham - Therapeutic advances in hematology, 2013 - journals.sagepub.com
Extensive research has been carried out in the past two decades to study the pathobiology
of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which is an oncogenic fusion …
of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), which is an oncogenic fusion …
Nucleophosmin–anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling …
RY Bai, T Ouyang, C Miething… - Blood, The Journal …, 2000 - ashpublications.org
More than half of anaplastic large-cell lymphomas (ALCLs) have a chromosomal
translocation t (2; 5) that leads to the expression of a hybrid protein composed of the …
translocation t (2; 5) that leads to the expression of a hybrid protein composed of the …
Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
A Slupianek, M Nieborowska-Skorska, G Hoser… - Cancer research, 2001 - AACR
The NPM/ALK fusion gene, formed by the t (2; 5) translocation in a subset of anaplastic large
cell lymphomas, encodes a M r 75,000 hybrid protein that contains the NH2-terminal portion …
cell lymphomas, encodes a M r 75,000 hybrid protein that contains the NH2-terminal portion …
Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis
D Bischof, K Pulford, DY Mason… - Molecular and cellular …, 1997 - Taylor & Francis
The NPM-ALK fusion gene, formed by the t (2; 5)(p23; q35) translocation in non-Hodgkin's
lymphoma, encodes a 75-kDa hybrid protein that contains the amino-terminal 117 amino …
lymphoma, encodes a 75-kDa hybrid protein that contains the amino-terminal 117 amino …