Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a …

Telmisartan Randomised AssessmeNt Study in ACE … - The Lancet, 2008 - Elsevier
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors reduce major
cardiovascular events, but are not tolerated by about 20% of patients. We therefore …

Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the …

Ontarget/transcend Investigators - American heart journal, 2004 - Elsevier
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors reduce mortality,
myocardial infarction, stroke, heart failure, need for revascularization, nephropathy, and …

Telmisartan, ramipril, or both in patients at high risk for vascular events

Ontarget Investigators - New England Journal of Medicine, 2008 - Mass Medical Soc
Background In patients who have vascular disease or high-risk diabetes without heart
failure, angiotensin-converting–enzyme (ACE) inhibitors reduce mortality and morbidity from …

From the HOPE to the ONTARGET and the TRANSCEND studies: challenges in improving prognosis

S Yusuf - The American journal of cardiology, 2002 - Elsevier
The Heart Outcomes Prevention Evaluation (HOPE) study conclusively demonstrated that
ramipril, an angiotensin-converting enzyme (ACE) inhibitor, reduces the risk of …

Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in …

P Verdecchia, P Sleight, G Mancia, R Fagard… - Circulation, 2009 - Am Heart Assoc
Background—Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor
blockers reduce left ventricular hypertrophy (LVH). The effect of these drugs on LVH in high …

Effects of telmisartan added to angiotensin-converting enzyme inhibitors on mortality and morbidity in hemodialysis patients with chronic heart failure: a double-blind …

G Cice, A Di Benedetto, S D'Isa, A D'Andrea… - Journal of the American …, 2010 - jacc.org
Objectives: The aim of this study was to determine whether telmisartan decreases all-cause
and cardiovascular mortality and morbidity in hemodialysis patients with chronic heart failure …

Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the …

CB Granger, JJV McMurray, S Yusuf, P Held… - The Lancet, 2003 - thelancet.com
Background Angiotensin-converting-enzyme (ACE) inhibitors improve outcome of patients
with chronic heart failure (CHF). A substantial proportion of patients, however, experience no …

Safety of telmisartan in patients with arterial hypertension: an open-label observational study

MC Michel, H Bohner, J Köster, R Schäfers… - Drug Safety, 2004 - Springer
Objective: To determine whether age, gender, concomitant disease and/or previous or
present antihypertensive medication affect the safety or antihypertensive efficacy of …

Angiotensin II and trials of cardiovascular outcomes

P Sleight - The American journal of cardiology, 2002 - Elsevier
Proven cardiovascular benefit from angiotensin-converting enzyme (ACE) inhibition is a
cornerstone of evidence-based medicine. The first study to show dramatic benefits from ACE …

Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in patients without heart failure? Insights from 254,301 patients from randomized trials

S Bangalore, R Fakheri, B Toklu, G Ogedegbe… - Mayo Clinic …, 2016 - Elsevier
Objectives To compare the efficacy and safety of angiotensin-converting enzyme inhibitors
(ACEis) and angiotensin receptor blockers (ARBs) in patients without heart failure. Patients …