Pharmacology of traumatic brain injury: where is the “golden bullet”?

K Beauchamp, H Mutlak, WR Smith, E Shohami… - Molecular …, 2008 - Springer
Traumatic brain injury (TBI) represents a major health care problem and a significant
socioeconomic challenge worldwide. In the United States alone, approximately 1.5 million …

Pharmacological treatment of traumatic brain injury: a review of agents in development

J Hatton - CNS drugs, 2001 - Springer
Successful treatment strategies for patients with traumatic brain injury (TBI) remain elusive
despite standardised clinical treatment guidelines, improved understanding of mechanisms …

Evaluation of pharmacological treatment strategies in traumatic brain injury

N Marklund, A Bakshi, DJ Castelbuono… - Current …, 2006 - ingentaconnect.com
Traumatic brain injury (TBI) is a devastating disease, predominantely affecting young
people. Although the prognosis for TBI victims has improved in recent years, many survivors …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy

PM Kochanek, H Bramlett, WD Dietrich… - Journal of Trauma …, 2011 - journals.lww.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in Operation Iraqi
Freedom largely due to the emergence of blast-injury from attacks with improvised explosive …

Neuroprotective strategies for traumatic brain injury: improving clinical translation

SV Kabadi, AI Faden - International journal of molecular sciences, 2014 - mdpi.com
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …

Traumatic brain injury pathophysiology and treatments: early, intermediate, and late phases post-injury

H Algattas, JH Huang - International journal of molecular sciences, 2013 - mdpi.com
Traumatic Brain Injury (TBI) affects a large proportion and extensive array of individuals in
the population. While precise pathological mechanisms are lacking, the growing base of …

Targets of neuroprotection and review of pharmacological interventions in traumatic brain injury

MI Hiskens - Journal of Pharmacology and Experimental …, 2022 - ASPET
Traumatic brain injury (TBI) is a major contributor to disability and death worldwide, and
manifests in cognitive, behavioral, and motor impairment. Although there have been …

Neuropharmacology in traumatic brain injury: from preclinical to clinical neuroprotection?

D Lerouet, C Marchand‐Leroux… - Fundamental & clinical …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) constitutes a major health problem worldwide and is a leading
cause of death and disability in individuals, contributing to devastating socioeconomic …

Recent advances in the development of multifactorial therapies for the treatment of traumatic brain injury

R Vink, C Van Den Heuvel - Expert opinion on investigational …, 2004 - Taylor & Francis
Traumatic brain injury (TBI) is one of the leading causes of death and disability in the
industrialised world and remains a major health problem with serious socioeconomic …