Histone modifications play critical roles in the epigenetic regulation of gene expression and
in the maintenance of genome integrity. Acetylation and methylation of histone H3 are …

Methylation of histone H4 at lysine 20 (K20) has been implicated in transcriptional activation,
gene silencing, heterochromatin formation, mitosis, and DNA repair. However, little is known …

The molecular biology of histone H4 lysine 20 (H4K20) methylation, like many other post-
translational modifications of histones, has been the subject of intensive interest in recent …

DNA in eukaryotic organisms does not exist free in cells, but instead is present as chromatin,
a complex assembly of DNA, histone proteins, and chromatin-associated proteins …

Mono-, di-, and trimethylation of specific histone residues adds an additional level of
complexity to the range of histone modifications that may contribute to a histone code …

Histone proteins constitute the core component of the nucleosome, the basic unit of
chromatin. Chemical modifications of histone proteins affect their interaction with genomic …

Histone acetylation, methylation, and phosphorylation occur predominantly in the
unstructured N‐terminal domains or histone “tails”. These modifications and others comprise …

The connections between various nuclear processes and specific histone posttranslational
modifications are dependent to a large extent on the acquisition of those modifications after …

We employ a stable isotope strategy wherein both histones and their methylations are
labeled in synchronized human cells. This allows us to differentiate between old and new …

Histone lysine acetylation is a major mechanism by which cells regulate the structure and
function of chromatin, and new sites of acetylation continue to be discovered. Here we …