Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi.
Recent research efforts have provided insight into the molecular mechanisms of the toxicity …

Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi.
The best-known ETP is gliotoxin, which appears to be a virulence factor associated with …

Background Genes responsible for biosynthesis of fungal secondary metabolites are usually
tightly clustered in the genome and co-regulated with metabolite production …

A gene, sirZ, encoding a Zn (II) 2Cys6 DNA binding protein is present in a cluster of genes
responsible for the biosynthesis of the epipolythiodioxopiperazine (ETP) toxin, sirodesmin …

Verticillin is one of the dimeric epipolythiodioxopiperazines (ETPs) which are toxic
secondary metabolites produced only by fungi. ETPs have received substantial attention …

Epipolythiodioxopiperazine toxins are secreted by a range of fungi, including Leptosphaeria
maculans, which produces sirodesmin, and Aspergillus fumigatus, which produces gliotoxin …

In this chapter, the toxicology and some aspects of the chemistry of a group of fungal
metabolites characterized by a bridge of sulfur atoms across a diketopiperazine ring is …

Epipolythiodioxopiperazines (ETPs) are a class of fungal secondary metabolites derived
from diketopiperazines. Acetylaranotin belongs to one structural subgroup of ETPs …

Gliotoxin is a secondary metabolite produced by several fungi including the opportunistic
animal pathogen Aspergillus fumigatus. It is a member of the epipolythiodioxopiperazine …

The epipolythiodioxopiperazine toxins are produced by a wide range of fungi. The
compounds in this group inhibit the growth of fungi, RNA viruses and gram-positive bacteria …