Aging and disease as modifiers of efficacy of cell therapy

S Dimmeler, A Leri - Circulation research, 2008 - Am Heart Assoc
Cell therapy is a promising option for treating ischemic diseases and heart failure. Adult
stem and progenitor cells from various sources have experimentally been shown to augment …

Stem cells and the regeneration of the aging cardiovascular system

VLT Ballard, JM Edelberg - Circulation research, 2007 - Am Heart Assoc
It is well established that cardiovascular repair mechanisms become progressively impaired
with age and that advanced age is itself a significant risk factor for cardiovascular disease …

Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges

J Tongers, DW Losordo… - European heart …, 2011 - academic.oup.com
In the absence of effective endogenous repair mechanisms after cardiac injury, cell-based
therapies have rapidly emerged as a potential novel therapeutic approach in ischaemic …

Cell-based therapy of myocardial infarction

S Dimmeler, J Burchfield, AM Zeiher - … , thrombosis, and vascular …, 2008 - Am Heart Assoc
Cell-based therapy is a promising option for treatment of ischemic diseases. Several cell
types have experimentally been shown to increase the functional recovery of the heart after …

Autologous stem cell therapy: how aging and chronic diseases affect stem and progenitor cells

AY Efimenko, TN Kochegura, ZA Akopyan… - BioResearch open …, 2015 - liebertpub.com
During recent years different types of adult stem/progenitor cells have been successfully
applied for the treatment of many pathologies, including cardiovascular diseases. The …

Cell-enhancement strategies for the treatment of ischemic heart disease

FH Seeger, AM Zeiher, S Dimmeler - Nature Clinical Practice …, 2007 - nature.com
Cell therapy is a promising option for the treatment of ischemic diseases. Infusion or
injection of stem or progenitor cells has improved neovascularization and heart function after …

[HTML][HTML] Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: combined consequences for cell therapy in older recipients

Y Zhuo, SH Li, MS Chen, J Wu, HYMD Kinkaid… - The Journal of thoracic …, 2010 - Elsevier
OBJECTIVE: Cell therapy has received much attention for its potential to regenerate
ischemic organs, but initial clinical trials in aged patients did not replicate the dramatic …

The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease

J Kim, L Shapiro, A Flynn - Pharmacology & Therapeutics, 2015 - Elsevier
Cardiovascular disease (CVD) can be separated into two broad etiological categories,
based on the presence or absence of ischemia as a causative factor. In both ischemic and …

Adult stem cell therapy for the heart

JK Fraser, RE Schreiber, PA Zuk, MH Hedrick - The international journal of …, 2004 - Elsevier
The purpose of this review is to summarize current data leading to and arising from recent
clinical application of cellular therapy for acute myocardial infarct (heart attack) and …

Adult bone marrow–derived cells: regenerative potential, plasticity, and tissue commitment

B Dawn, R Bolli - Basic research in cardiology, 2005 - Springer
Reconstitution of infarcted myocardium with functional new cardiomyocytes and vessels, a
goal that only a few years ago would have been regarded as extravagant, is now actively …