From brain to bone: evidence for the release of osteogenic humoral factors after traumatic brain injury

AM Toffoli, OP Gautschi, SP Frey, L Filgueira… - Brain Injury, 2008 - Taylor & Francis
Primary objective: The aetiology of the increased osteogenesis associated with severe
traumatic brain injury (TBI) remains incompletely understood. The purpose of this article is to …

Serum‐mediated osteogenic effect in traumatic brain‐injured patients

OP Gautschi, D Cadosch, SP Frey… - ANZ journal of …, 2009 - Wiley Online Library
Background: Patients with a traumatic brain injury (TBI) and bone fractures often show an
enhanced fracture healing, as well as an increased incidence of heterotopic ossifications …

Serum after traumatic brain injury increases proliferation and supports expression of osteoblast markers in muscle cells

D Cadosch, AM Toffoli, OP Gautschi, SP Frey… - JBJS, 2010 - journals.lww.com
Background: Traumatic brain injury is associated with an increased rate of heterotopic
ossification within skeletal muscle, possibly as a result of humoral factors. In this study, we …

Osteoinductive effect of cerebrospinal fluid from brain-injured patients

OP Gautschi, AM Toffoli, KA Joesbury… - Journal of …, 2007 - liebertpub.com
Patients with traumatic brain injury (TBI) are predisposed to heterotopic ossification, which is
believed to be due to osteoinductive factors released at the site of the brain injury. To date …

Functional and proteomic analysis of serum and cerebrospinal fluid derived from patients with traumatic brain injury: a pilot study

D Cadosch, M Thyer, OP Gautschi… - ANZ journal of …, 2010 - Wiley Online Library
Background: An enhanced fracture healing response has been reported in patients with
traumatic brain injury (TBI). This has been attributed to circulating humoral factors that are …

Does traumatic brain injury result in accelerated fracture healing?

J Morley, S Marsh, E Drakoulakis, HC Pape… - Injury, 2005 - Elsevier
In patients who have sustained a traumatic brain injury with an associated extremity fracture
there is often a clinical perception that the rate of new bone formation around the fracture …

Humoral factors enhance fracture-healing and callus formation in patients with traumatic brain injury

D Cadosch, OP Gautschi, M Thyer, S Song, AP Skirving… - JBJS, 2009 - journals.lww.com
Background: Scientific evidence is mounting for an association between traumatic brain
injury and enhanced osteogenesis. The aim of this study was to correlate the in vitro …

[PDF][PDF] The pathogenesis of heterotopic ossification after traumatic brain injury. A review of current literature

J Anthonissen, CT Steffen, A Hofmann… - Acta Orthop …, 2020 - actaorthopaedica.be
Neurogenic heterotopic ossification (NHO), mostly defined as a benign process of formation
of bone outside the skeletal system, after traumatic brain injury (TBI) is a musculoskeletal …

Evaluation of serum osteoblast mitogenic activity in spinal cord and head injury patients with acute heterotopic ossification

KJ Renfree, K Banovac, FJ Hornicek, NH Lebwohl… - Spine, 1994 - journals.lww.com
Study Design: This was a blind, prospective study of the effect of sera from patients with
spinal cord and head injuries on osteoblast proliferation. Objectives: The authors studied …

[HTML][HTML] Relationship between heterotopic ossification and traumatic brain injury: why severe traumatic brain injury increases the risk of heterotopic ossification

H Huang, WX Cheng, YP Hu, JH Chen… - Journal of orthopaedic …, 2018 - Elsevier
Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone
forms in soft tissues. HO involves many predisposing factors, including congenital and …