Despite the clear roles played by peroxisome proliferators-activated receptor α (PPAR-α) in
lipid metabolism, inflammation and feeding, the effects of its activation in the central nervous …

Peroxisome proliferator-activated receptor (PPAR)-α is a nuclear transcription factor.
Although the presence of this receptor in different areas of central nervous system (CNS) …

Palmitoylethanolamide (PEA), the naturally occurring amide of palmitic acid and
ethanolamine, reduces pain and inflammation through an as-yet-uncharacterized …

Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in
endogenous protective mechanisms activated as a result of stimulation of inflammatory …

Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous
system are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic …

Background and purpose: We have previously demonstrated antinociceptive effects of fatty
acid amide hydrolase (FAAH) inhibition that were accompanied by increases in the levels of …

Oleoylethanolamide (OEA) is a natural fatty acid amide that mainly modulates feeding and
energy homeostasis by binding to peroxisome proliferator-activated receptor-alpha (PPAR …

The neural substrates and mechanisms mediating the antinociceptive effects of the
endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation …

Chronic pain presents a widespread and intractable medical problem. While numerous
pharmaceuticals are used to treat chronic pain, drugs that are safe for extended use and …

Severe pain remains a major area of unmet medical need. Here we report that agonists of
the nuclear receptor PPAR-α (peroxisome proliferator-activated receptor-α) suppress pain …