AIMS: Recently, we demonstrated that cultured mouse astrocytes exhibited basal channel
opening of P2X7 receptor (P2X7R) in the absence of any exogenous ligand, but the …

Abstract P2X7 receptors (P2X7Rs) gate the opening of large channels when activated by
ATP or other ligands. P2X7Rs are expressed by astrocytes in culture and by reactive …

Of purinergic receptors, P2X7 receptor (P2X7R, defined as a full‐length receptor) has
unique characteristics, and its activation leads to ion channel activity and pore formation …

The role of the interaction between neurons and glial cells in the pathogenesis of
neurodegenerative diseases is gaining more attention. Neuroinflammation participates in …

P2X 7 receptor is a ligand-gated ion channel, which can induce the opening of large
membrane pores. Here, we provide evidence that the receptor induces pore formation in …

We previously demonstrated that P2X7 receptors (P2X7Rs) expressed by cultured mouse
astrocytes were activated without any exogenous stimuli, but its roles in non-stimulated …

P2X receptors are a family of seven (P2X1–7) cation channels gated by extracellular ATP,
widely expressed in neurons and nonneuronal cells. Lipid rafts are cholesterol/sphingolipid …

Abstract The ATP-gated P2X7R (P2X7R) is a channel, which is involved in events, such as
inflammation, cell death, and pain. The most intriguing event concerning P2X7R functions is …

Activation of the ATP-gated P2X7 receptor (P2X7R), implicated in numerous diseases of the
brain, can trigger diverse responses such as the release of pro-inflammatory cytokines …

Microglial activation is an integral part of neuroinflammation associated with many
neurodegenerative conditions. Interestingly, a number of neurodegenerative conditions …