Lactate uses an unknown mechanism to induce panic attacks in people and panic-like
symptoms in rodents. We tested whether intraperitoneal (IP) lactate injections act …

Patients with panic disorder experience panic attacks after intravenous sodium lactate
infusions by an as yet unexplained mechanism. Lactate elicits a panic-like response in rats …

Glucose is well accepted as the major fuel for neuronal activity, while it remains
controversial whether lactate also supports neural activity. In hippocampal slice cultures …

Converging evidence suggests that patients with panic disorder have a metabolic
disturbance that may influence the regulation of arousal systems and confer vulnerability to …

BACKGROUND: Prior evidence suggests panic disorder (PD) is characterized by
neurometabolic abnormalities, including increased brain lactate responses to neural …

Intravenous sodium lactate infusion is a robust laboratory technique for eliciting panic in
susceptible individuals. The objective for this study was to replicate previous work which …

Panic disorder is a severe anxiety disorder characterized by susceptibility to induction of
panic attacks by subthreshold interoceptive stimuli such as 0.5 M sodium lactate infusions …

Background A fast, proton echo-planar spectroscopic imaging (PEPSI) technique, capable of
simultaneously measuring metabolites from multiple brain regions, was used to investigate …

During the initial minutes of cerebral ischemia, lactic acid accumulates and acidifies brain
pH to 6.0–6.7. Glutamate is also released during ischemia that activates glutamate receptors …

Lactate is considered an important metabolite in the human body, but there has been
considerable debate about its roles in brain function. Research in recent years has …