Hyperexcitability of C-fiber bladder afferent pathways has been proposed to contribute to
urinary frequency and bladder pain in chronic bladder inflammation including interstitial …

The internal surface of the urinary bladder is covered by the urothelium, a stratified
epithelium that forms an impermeable barrier to urinary solutes. Increased urothelial …

Purpose: To clarify the functional and molecular mechanisms inducing hyperexcitability of C-
fiber bladder afferent pathways after spinal cord injury we examined changes in the …

The properties of bladder afferent neurons in L6 and S1 dorsal root ganglia of adult rats
were evaluated after chronic bladder inflammation induced by 2 week treatment with …

Aims Kv7 voltage‐gated potassium channels have been suggested to modulate mechano‐
afferent transduction and nociception in the bladder. We investigated the effects of …

Key points KV7 channels are a family of voltage‐dependent K+ channels expressed in many
cell types, which open in response to membrane depolarization to regulate cell excitability …

When the urinary bladder is full, activation of parasympathetic nerves causes release of
neurotransmitters that induce forceful contraction of the detrusor muscle, leading to urine …

Purpose: We determined whether voltage gated K+ (KV) channels are expressed and
functional in human detrusor smooth muscle Materials and Methods: Information on KV …

Voltage-gated Kv7 (KCNQ) channels are emerging as essential regulators of smooth muscle
excitability and contractility. However, their physiological role in detrusor smooth muscle …

The internal surface of the bladder is lined by the urothelium, a stratified epithelium that
forms an impermeable barrier to water and urine constituents. Abnormalities in the urothelial …