Acute neuroprotection by pioglitazone after mild brain ischemia without effect on long-term outcome

S Ji, G Kronenberg, M Balkaya, K Färber, K Gertz… - Experimental …, 2009 - Elsevier
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists (thiazolidinediones)
have anti-inflammatory effects and improve endothelium function. Here, we analyzed the …

Neuroprotection against focal ischemic brain injury by the peroxisome proliferator‐activated receptor‐γ agonist rosiglitazone

Y Luo, W Yin, AP Signore, F Zhang… - Journal of …, 2006 - Wiley Online Library
Peroxisome proliferator‐activated receptor gamma (PPAR‐γ) is a nuclear membrane‐
associated transcription factor that governs the expression of various inflammatory genes …

The intracerebral application of the PPARγ‐ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain

Y Zhao, A Patzer, P Gohlke… - European Journal of …, 2005 - Wiley Online Library
The present study addresses the neuroprotective function of intracerebroventricular (icv)
application of pioglitazone, a selective ligand of the peroxisome proliferator‐activated …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) activation confers functional neuroprotection in global ischemia

Z Fatehi-Hassanabad, RA Tasker - Neurotoxicity research, 2011 - Springer
The neuroprotective effect of rosiglitazone, a peroxisome proliferator-activated receptor γ
(PPARγ) agonist, has been investigated using both in vivo and in vitro models of global …

Treatment of rats with pioglitazone in the reperfusion phase of focal cerebral ischemia: a preclinical stroke trial

J Culman, M Nguyen-Ngoc, T Glatz, P Gohlke… - Experimental …, 2012 - Elsevier
Thiazolidinediones (TZDs), pioglitazone, rosiglitazone and troglitazone, the synthetic
agonists for the PPARγ, administered prior or during ischemic insult improve stroke outcome …

Rosiglitazone promotes white matter integrity and long-term functional recovery after focal cerebral ischemia

L Han, W Cai, L Mao, J Liu, P Li, RK Leak, Y Xu, X Hu… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—Oligodendrogenesis is essential for white matter repair after
stroke. Although agonists of peroxisome proliferator–activated receptors γ confer …

Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats

CX Wang, X Ding, R Noor, C Pegg… - Journal of Cerebral …, 2009 - journals.sagepub.com
In this study, we examined whether rosiglitazone, a peroxisome proliferator-activated
receptor gamma (PPAR γ) agonist, is neuroprotective in focal ischemic brain injury, and …

Peroxisome proliferator‐activated receptor‐γ agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as …

K Tureyen, R Kapadia, KK Bowen… - Journal of …, 2007 - Wiley Online Library
Thiazolidinediones (TZDs) are synthetic agonists of the ligand‐activated transcription factor
peroxisome proliferator‐activated receptor‐γ (PPARγ). TZDs are known to curtail …

Altered PPARγ expression and activation after transient focal ischemia in rats

NA Victor, EW Wanderi, J Gamboa… - European Journal of …, 2006 - Wiley Online Library
Stroke is a devastating disease with limited treatment options. Recently, we found that the
peroxisome proliferator‐activated receptor‐γ (PPARγ) agonists troglitazone and …

Peroxisome proliferator-activated receptor-γ-agonist, rosiglitazone, promotes angiogenesis after focal cerebral ischemia

K Chu, ST Lee, JS Koo, KH Jung, EH Kim, DI Sinn… - Brain research, 2006 - Elsevier
Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, rosiglitazone, not only
improves insulin resistance in patients with type II diabetes but also exerts a broad spectrum …