A 5th type of hypersensitivity reaction: Does incidental recruitment of autoreactive effector memory T-cells in response to minute amounts of PAMPs or DAMPs …

PEA Gray - Medical hypotheses, 2009 - Elsevier
There are many documented associations of the HLA B27-related diseases–the
seronegative arthropathies (SNAs) and acute anterior uveitis (AAU). However, to date no …

[HTML][HTML] Autoinflammation and HLA-B27: More than an Antigen

CH Sibley - Ocular immunology and inflammation, 2016 - ncbi.nlm.nih.gov
Spondyloarthritides comprise a group of inflammatory conditions which have in common an
association with the MHC class I molecule, HLA-B27. Given this association, these diseases …

[HTML][HTML] Cytokines and chemokines involved in HLA-B27-positive ankylosing spondylitis-associated acute anterior uveitis

H Li, Z He, B Deng, C Yang, L Wang, J Xiao… - Molecular …, 2023 - ncbi.nlm.nih.gov
Purpose Acute anterior uveitis (AAU) is the most common extra-articular symptom of
ankylosing spondylitis (AS). This study aims to reveal the cytokines and chemokines …

Autoinflammation and HLA-B27: beyond antigen presentation

CH Sibley - Ocular Immunology and Inflammation, 2016 - Taylor & Francis
ABSTRACT HLA-B27 associated disorders comprise a group of inflammatory conditions
which have in common an association with the HLA class I molecule, HLA-B27. Given this …

An update on the genetics of HLA B27-associated acute anterior uveitis

TM Martin, JT Rosenbaum - Ocular immunology and inflammation, 2011 - Taylor & Francis
The discovery of the association of HLA B27 with spondyloarthropathy led to more questions
than answers about the role of this gene in disease susceptibility. The realization that HLA …

[HTML][HTML] The phenotype of monocytes in anterior uveitis depends on the HLA-B27 status

M Kasper, K Walscheid, B Laffer, D Bauer… - Frontiers in …, 2018 - frontiersin.org
HLA-B27 is the allele most frequently associated with human anterior uveitis. The majority of
HLA-B27-positive [acute anterior uveitis (AAU)] patients develop clinically distinct symptoms …

[HTML][HTML] Recent developments in HLA B27 anterior uveitis

D Wakefield, D Clarke, P McCluskey - Frontiers in Immunology, 2021 - frontiersin.org
There has been steady progress in understanding the pathogenesis, clinical features, and
effective treatment of acute anterior uveitis (AU) over the past 5 years. Large gene wide …

Cytokine expression profile in aqueous humor and sera of patients with acute anterior uveitis

W Chen, B Zhao, R Jiang, R Zhang… - Current Molecular …, 2015 - ingentaconnect.com
Purpose: To evaluate cytokine expression profile in aqueous humor and sera in patients
with HLAB27 associated acute anterior uveitis (AAU) and idiopathic AAU. Methods: Twenty …

Acute anterior uveitis and HLA-B27: what's new

JH Chang, PJ McCluskey, D Wakefield - Uveitis and Immunological …, 2009 - Springer
■ Bacterial triggers have been strongly implicated in the development of AAU and recurrent
episodes of ocular inflammation.■ Human uveal antigen-presenting cells express TLR4, the …

Comment onPosterior segment inflammation in HLA-B27+ acute anterior uveitis: clinical characteristics'

A Rothova - Ocular Immunology and Inflammation, 2000 - Taylor & Francis
In their article entitled 'Posterior segment inflammation in HLA-B27+ acute anterior uveitis:
clinical characteristics'(published in Ocular Immunology and Inflammation 1999; 7: 85-92) …