Covalent modifications of intracellular proteins, such as phosphorylation, are generally
thought to occur as secondary or tertiary responses to neurotransmitters, following the …

Children with acute lymphoblastic leukemia (ALL) diagnosed with resistant phenotypes, and
those who relapse, have a dismal prognosis for cure. The antifolate methotrexate (MTX), a …

p300/CREB binding protein-associated factor (PCAF) regulates gene expression by acting
through histone acetylation and as a transcription coactivator. Although histone …

Histone acetylation is one of the key regulatory mechanisms controlling transcriptional
activity in eukaryotic cells. In higher eukaryotes, a number of nuclear histone …

Abstract Background Histone acetyltransferase enzymes (HATs) are implicated in regulation
of transcription. HATs from different families may overlap in target and substrate specificity …

Epigenetics is an essential mechanism to control gene expression and fundamental cellular
processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone …

We have previously demonstrated that histone deacetylase 7 (HDAC7) expression and
splicing play an important role in smooth muscle cell (SMC) differentiation from embryonic …

Many of the physiological actions of GH are mediated by IGF-I, a secreted 70-residue
peptide whose gene expression is induced by GH in the liver and other tissues via …

GCN5 encodes one of the non-essential Histone Acetyl Transferases in Saccharomyces
cerevisiae. Extensive evidence has indicated that GCN5 is a key regulator of gene …

FoxA1–3 (formerly HNF3α,-β, and-γ), members of the FoxA subfamily of forkhead
transcription factors, function as initial chromatin-binding and chromatin-remodeling factors …